心血管风险评分越高，认知功能越低

A risk calculator used to predict cardiovascular disease also may help predict a person's poor cognitive function, 新的研究表明.

这项研究发表在周二的《沙巴足球体育平台》杂志上 美国心脏协会杂志, 发现一个人10年心血管风险评分越高, 他们在认知功能测试中得分越低, adding to a large body of evidence suggesting that controlling heart-health risk factors may help protect brain health.

"We know that cardiovascular disease shares a lot of risk factors with cognitive decline or dementia,该研究的合著者魏景凯说, who holds a doctorate in epidemiology and is an assistant professor at the University of South Carolina's Arnold School of Public Health in Columbia. The results suggest every 5% increment in the cardiovascular disease risk score may be related to poorer cognitive functioning, he said.

Cardiovascular disease includes heart disease, stroke, heart failure and high blood pressure. 在美国，心脏病是导致死亡的主要原因.S.，在第11号中风. 5. About 5.800万美元.S. 成年人有某种形式的痴呆症.

Previous studies have shown an association between higher cardiovascular risk scores and poorer cognitive function in people with preexisting health conditions. The new study examined the link between cardiovascular risk scores and cognitive function in a larger sample of the general population and differences among racial and ethnic subgroups.

The Framingham risk score is used to calculate a person's 10-year and lifetime risk of developing cardiovascular disease. 分数是用年龄来计算的, sex, race, 总胆固醇, “好的”高密度脂蛋白胆固醇, 收缩压(最高值), 一个人是否服用降血压药物, 以及他们是否有糖尿病或吸烟.

在研究中, researchers analyzed data from the National Health and Nutrition Examination Survey from 2011 to 2014 for 2,254名成年人, 60岁及以上, 谁以前没有被诊断患有心血管疾病. Researchers calculated 10-year Framingham risk scores for participants using self-reported data from questionnaires and blood tests for cholesterol, 血糖和糖化血红蛋白水平. 同时还测量了多个血压读数并取平均值. 然后将风险评分分为低、中、高三个等级.

Cognitive function was measured using three tests – the Consortium to Establish a Registry for Alzheimer's Disease Word List Memory Task, 数字符号替代测试和动物流畅性测试.

Participants with medium and high Framingham risk scores had lower cognitive scores than those with low cardiovascular risk scores. 随着弗雷明汉分数的提高，整体认知测试分数下降.

"This adds to the growing body of evidence that shows it's important to take care of cardiovascular health, 不仅仅是对心脏的影响, 而是对大脑健康的影响," said Dr. Kristine Yaffe, a professor at the Weill Institute for Neurosciences at the University of California, 旧金山. 亚菲没有参与这项研究.

“对心脏有益的东西对大脑也有益，”她说.

然而，亚组之间的结果有所不同. Cardiovascular risk factors were linked to poorer cognitive function among Hispanic people, 但这种联系在非西班牙裔白人中最为明显. The link between higher cardiovascular risk scores and lower cognitive function did not hold up among Black people.

That doesn't mean cardiovascular risk factors don't contribute to cognitive decline in Black people, Wei said, noting that participants in the decades-long Framingham Heart Study were predominantly white people of European descent.

"The calculator may not predict outcomes as well for African Americans," he said.

The findings may suggest that reducing cardiovascular risk factors could be a strategy for preventing cognitive decline, Wei said.

While some of the risk factors in the Framingham calculator can't be changed, 很多都可以, Yaffe说.

“你对自己的年龄无能为力，”她说. "But you can make sure that if you have risk factors such as high blood pressure, diabetes, 高胆固醇或肥胖, that you work with your health care professional to make sure you are getting treatment and also engaging in healthy lifestyle behaviors like exercising and eating a healthy diet."